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KMID : 0387720170280020113
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Korean Journal of Blood Transfusion
2017 Volume.28 No. 2 p.113 ~ p.125
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The Current Global Status and Production Trends of Plasma Fractionation
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Kim Moon-Jung
Thierry Burnouf
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Abstract
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The demand for medicinal products derived from plasmas are increasing on a global scale. In particular, the demand for intravenous immunoglobulin has continuously been increasing. The increase in the capacity of commercial plasma fractionators is prominent compared with that of non-profit plasma fractionators; thus, the percentage of plasmapheresis has increased with respect to that of plasma from whole blood. The inequality between the consumption of plasma-derived medicinal products and supply of raw plasma among developed countries and developing countries is due to the direct, proportional relationship between the consumption of plasma-derived medicinal products and the size of gross domestic products. Each country decides on its own system to achieve a stable supply of plasma-derived medicinal products. Although domestic production is an ideal option, many countries establish contracts with plasma fractionators. Owing to a great ripple effect, safety measures are increasingly applied, so detailed review should be conducted with consideration given to the cost-effectiveness and the situation unique to each country.
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KEYWORD
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Plasma-derived medicinal products, Plasma fractionation, Immunoglobulin, Coagulation factor, Albumin
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